St. Bartholomew's Day Massacre led to the death of many _____.

The St. Bartholomew's Day Massacre, which took place in France in 1572, was a significant event during the French Wars of Religion between Catholics and Huguenots (French Protestants). The massacre was initiated by the Catholic establishment, particularly under the influence of Catherine de' Medici, against Huguenots who were attending the wedding of Henry of Navarre (a Huguenot) and Margaret of Valois (a Catholic). The violence resulted in the death of thousands of Huguenots, particularly those of noble rank, as they were targeted due to their prominent roles in the Protestant movement. This brutal act not only marked a turning point in the religious conflict but also exemplified the intense animosity and violence between Catholics and Huguenots at the time. Thus, the Huguenot nobility suffered the greatest fatalities during this tragic event, making this option the correct answer.